I saw this today: Inflammation Linked to Chemo Brain.
A new study reports inflammation in the blood may play a role in cognitive problems following chemotherapy. Researchers report identifying the inflammatory biomarkers and reducing inflammation may prevent some of the symptoms of chemo brain.
…Chemo-brain, or cancer-related cognitive impairment, is estimated to impact 80 percent of people in treatment. Patients report fogginess, forgetfulness, and difficulty with multitasking and other problem-solving skills.
Researchers discovered that one particular biomarker for acute inflammation—tumor necrosis factor-alpha—was the strongest indicator of cognitive problems.
…Last year another study led by Janelsins —one of the largest to date for this problem—showed that women with breast cancer continued to report cognitive deficits for as long as six months after finishing treatment. That study not only validated that chemo-brain was pervasive, but Janelsins and her team also began parsing the data to understand the biological mechanisms, such as inflammation, that may put some patients at greater risk for chemo-brain.
Chemo brain has been one of the things that makes me hesitate about methotrexate. I didn’t know that the rates chemo brain were that high. How does one reduce inflammation before taking the medication that has been prescribed to reduce the inflammation?
Is anyone out there on methotrexate for autoimmune conditions who has noticed cognitive problems?